At present, the loss reduction and energy saving transformation of distribution network is a systematic project by means of equipment renewal, grid structure optimization, grid reconfiguration, reactive power compensation and operation optimization. There are a lot of researches on loss reduction and energy-saving schemes for distribution network at home and abroad, but for the optimization of loss reduction measures, there are many problems such as single loss reduction method and difficult to form a system of scheme combination optimization. Moreover, few studies have been done on the optimization model of loss reduction schemes considering low carbon efficiency. In view of this, this paper establishes various loss reduction measures corresponding to the energy efficiency index of distribution network, considers the low-carbon benefits brought by loss reduction, and puts forward a combination optimization model and method of loss reduction schemes of distribution network taking into account the low-carbon benefits. The example of IEEE-14 node proves that the proposed model and method have good maneuverability.